A patient with Melkersson-Rosenthal Syndrome can be identified by the presence of a number of clinical findings.
(1) recurrent orofacial edema, including the lips
(2) intermittent paralysis of the facial nerve
(3) furrowed tongue (lingua plica)
Biopsy of an edematous lip may show granulomatous inflammation (granulomatous cheilitis).
Number of Clinical Features
Granulomas on Lip Biopsy
Diagnosis (after exclusion of other conditions)
(1) Crohn's disease
(3) mycobacterial infection
(4) deep fungal infection
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