Clinical Features of Melkersson-Rosenthal Syndrome

A patient with Melkersson-Rosenthal Syndrome can be identified by the presence of a number of clinical findings.

Clinical findings:

(1) recurrent orofacial edema, including the lips

(2) intermittent paralysis of the facial nerve

(3) furrowed tongue (lingua plica)

Biopsy of an edematous lip may show granulomatous inflammation (granulomatous cheilitis).

Number of Clinical Features	Granulomas on Lip Biopsy	Diagnosis (after exclusion of other conditions)
3	NA	definite
2	present	definite
2	NA	probable
1	present	probable
1	NA	possible

Differential diagnosis:

(1) Crohn's disease

(2) sarcoidosis

(3) mycobacterial infection

(4) deep fungal infection

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