Patient selection: pediatric patient receiving cisplatin infusions for cancer
Types of acute kidney injury:
(1) rise in serum creatinine using the KDIGO definition (>= 1.5 times baseline)
(2) electrolyte abnormalities (hypomagnesemia, hypokalemia, hypophosphatemia, tubular acidosis) associated with tubular damage, using the NCI CTC-AE
Cisplatin-associated AKI is not oliguric, so urine output criteria are not used.
Risk factors differ between early and late therapeutic visits.
Risk factors for AKI in the early visits (first 2 cycles):
(1) central nervous system tumors or neuroblastoma
(2) higher eGFR prior to first infusion
Risk factors for AKI in the late visits (last 2 cycles):
(1) age < 3 years
(2) neuroblastoma
(3) higher cisplatin infusion dose
(4) higher eGFR prior to the last infusions
Complications of repeated episodes of cisplatin-associated AKI:
(1) chronic kidney disease
(2) hypertension
