Majeed is a rare genetic disorder that has affected families in the Middle East.

Chromosome: 18p11.31

Gene affected: LPIN2

Inheritance: autosomal recessive


Clinical findings:

(1) chronic recurrent multifocal osteomyelitis (CRMO)

(2) congenital dyserythropoietic anemia with hypochromic, microcytic anemia

(3) variable inflammatory dermatosis including Sweet's syndrome

(4) short stature as an adult

(5) variable transient cholestatic jaundice in the neonatal period



(1) disuse atrophy of muscles

(2) contractures

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