Familial Hyperaldosteronism Type 2 (FH2) is a rare, hereditary cause of hyperaldosteronism.


Genetic Locus: 7p22


Genes Affected: uncertain


Gene Mutation: uncertain


Inheritance: autosomal dominant


A patient may have bilateral adrenocortical hyperplasia and/or adrenocortical adenomas.


Clinical features:

(1) hypertension

(2) failure of glucocorticoid therapy (dexamethasone, other) to control the hypertension


Laboratory findings:

(1) elevated plasma aldosterone levels

(2) low plasma renin activity

(3) absence of the chimeric gene associated with FH1


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