Clinical findings suggesting cystitis:
(1) dysuria
(2) hematuria, which may be gross
(3) urinary frequency or retention
(4) lower abdominal pain
(5) occasionally a palpable suprapubic mass
(6) occasionally nocturia
Concurrent findings may include:
(1) eosinophilia in the peripheral blood
(2) history of allergy
(3) asthma
(4) eosinophilic infiltrates in GI tract
(5) eosinophiluria
(6) allergic skin rash
Imaging findings:
(1) thickened, irregular bladder wall
(2) mass lesion
(3) vesicoureteral reflux
Findings on cystoscopy:
(1) normal mucosa (diagnosis may be missed if biopsies are not taken)
(2) mucosal edema and erythema
(3) plaque-like lesions
(4) necrotic ulcerations
Pathologic findings on bladder wall biopsy:
(1) eosinophilic infiltrate in the lamina propria and muscularis propria
A few patients may have progressive disease with diffuse bladder fibrosis and an obstructive uropathy.
Differential diagnosis:
(1) bacterial cystitis (which may be present concurrently)
(2) interstitial cystitis
(3) malacoplakia
(4) bladder tumor
