A patient undergoing long-term hemodialysis may accumulate beta2-microglobulin, which may become deposited as a form of amyloidosis.


Patient selection: long-term hemodialysis


Clinical findings:

(1) degenerative osteoarthritis (amyloid arthropathy)

(2) bone cysts with or without fracture

(3) carpal tunnel syndrome

(4) cutaneous papules and plaques

(5) subcutaneous nodules

(6) lingual papules

(7) mucosal ulcerations in the gastrointestinal tract which can result in GI bleeding


Laboratory testing often shows an elevated beta2-microglobulin fraction in the serum protein.


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