Severe iodine deficiency during a pregnancy can result in the fetus becoming a cretin.
Consequences of severe iodine deficiency during pregnancy:
(1) stillbirth with abortion
(2) congenital malformations
If the fetus survives to birth, then the patient may show the neurologic pattern, the myxedematous pattern, or both (mixed pattern).
Neurologic-type of cretin:
(1) severe mental retardation
(3) spastic diplegia
(1) short stature
(2) hypothyroidism with goiter
(3) severe mental retardation
Factors affecting severity of the syndrome:
(1) severity of the iodine deficiency during the pregnancy
(2) ongoing iodine deficiency
(3) amount of iodine replacement received
(4) other nutritional and health issues
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