Essential diagnostic features:
(1) inflammatory eye disease (interstitial keratitis, iritis, uveitis, scleritis and/or episcleritis)
(2) sudden-onset sensorineural hearing loss (hypoacusis, hypacusis)
(3) exclusion of syphilis, toxic effect, hereditary condition and infection
Clinical findings:
(1) history of cigarette smoking
(2) vasculitis
(3) vertigo or tinnitus
(4) ataxia
(5) oscillopsia
(6) nystagmus
(7) headache
(8) arthralgia or arthritis
(9) fever
(10) myalgia
(11) conjunctivitis
(12) photophobia
(13) rash
(14) aortitis or aortic sclerosis
(15) peripheral neuropathy
Laboratory findings:
(1) anemia
(2) leukocytosis
(3) thrombocytosis
(4) elevated ESR
(5) elevated CRP
(6) antineutrophil cytoplasmic antibody with perinuclear pattern (occasional)
