Site of initial case: Bourbon County, Kansas
Virus: genus Thogotovirus (family Orthomyxoviridae)
Transmission: presumed tickborne
Clinical features:
(1) fever
(2) nausea
(3) diarrhea
(2) anorexia
(4) myalgia and arthralgia
(5) headache
(6) chills
(7) absence of respiratory symptoms initially
(8) altered mental status
(9) diffuse maculopapular rash
(10) lymphadenopathy
(11) multi-organ failure
(12) failure to respond to doxycycline
Laboratory features:
(1) leucopenia
(2) thrombocytopenia
(3) elevated liver function tests
Diagnosis involves exclusion of other causes.
A confirmed case should have evidence of virus RNA by RT-PCR or rise in antibody titer.
