A patient with sickle anemia may suddenly sequester red blood cells in the liver, often with sequestration in other organs.


Clinical features of acute hepatic sequestration:

(1) acute right upper quadrant pain

(2) increasing hepatomegaly

(3) falling hemoglobin and hematocrit

(4) rise in hemoglobin and hematocrit with decline in liver size as the process resolves

(5) little or no changes in liver function tests


Other organs where sequestration may occur:

(1) lungs

(2) spleen


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