Some patients with a monkeypox infection can have a severe disease that may be fatal.
Risk factors for severe monkeypox infection include:
(1) HIV or AIDS
(2) other causes of immunodeficiency
(3) immunosuppression
(4) pediatric age group
Clinical and laboratory features:
(1) widespread skin lesions (>= 100), which may be confluent
(2) mucosal lesions (oral, anal, vaginal, urethral, GI tract)
(3) fever with temperature >= 38.3°C
(4) severe lymphadenopathy, which can be necrotizing
(5) neurologic symptoms (encephalitis, transverse myelitis)
(6) myocarditis and/or pericarditis
(7) pulmonary nodules
(8) severe conjunctivitis and/or corneal ulcerations
(9) multi-organ failure
(10) high baseline viremia
Complications:
(1) sepsis
(2) secondary bacterial or fungal skin infection
(3) stricture and/or scarring
