Histamine can exert a number of clinical effects some of which are concentration dependent.
Histamine acts through 4 types of receptors on target cells.
smooth muscle, endothelial cells, central nervous system
gastric parietal cells, myocytes, mast cells, central nervous system
presynaptic nerve nerve fibers (affects nocioceptive fibers), myenteric plexus
Clinical effects are mediated by:
(1) smooth muscle contraction
(2) vasodilatation and increased vascular permeability
(3) mucous gland secretion
(4) increased gastric acid secretion
(5) altered CNS functions
Signs and symptoms may include:
(3) cardiac arrhythmias
(4) changes in blood pressure (hypertension or hypotension)
(5) dysmenorrhea in females
(6) abdominal cramps
(8) nausea and vomiting
(9) bronchoconstriction/bronchospasm (asthma) and dyspnea
(10) rhinorrhea and nasal congestion
(11) urticaria and pruritis
(12) cutaneous flushing
(14) excess gastric acid (peptic ulcer disease, GERD)
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Specialty: Endocrinology, Clinical Laboratory, Immunology/Rheumatology, Otolaryngology, Dermatology