Required criteria:
(1) worsening symptoms of inflammation and/or infection
(2) onset after starting HAART
(3) >= 1 LOG10 decrease in plasma HIV load (10-fold decrease, or ratio of post-treatment count to pre-treatment count less than 0.1)
(4) symptoms not due to the onset of a newly acquired infection or disease
(5) symptoms not explained by the usual course of an existing disease
where:
• Criteria 4 and 5 are listed as a single criterion with a connecting OR.
• Criterion 5 can be interpreted in different ways. It may be referring to noninfectious conditions (criterion 4 specifies "infection or disease"). Since a patient with HIV does not have a normal immune system, any infection would not show a "usual" course?
Supportive criteria:
(1) an increase in CD4 positive lymphocytes >= 25 per µL
(2) A biopsy shows well-formed granulomatous inflammation or an unusually exuberant inflammatory response
