Nonbacterial endocarditis consists of sterile vegetations on one or more cardiac valves. This condition may be encountered in a number of disorders, many of which are chronic and associated with a hypercoagulable state.


Synonyms: marantic ("wasting away") endocarditis, degenerative verrucal endocarditis, Libman-Sacks endocarditis (in SLE)


Causes of nonbacterial endocarditis:

(1) carcinomas

(2) connective tissue disorders

(3) other chronic diseases


Carcinomas associated with nonbacterial endocarditis:

(1) pancreatic carcinoma

(2) squamous cell carcinoma of the head and neck

(3) ovarian cancer

(4) lung cancer

(5) malignant lymphoma

(6) mucinous adenocarcinoma

(7) breast cancer

(8) prostate cancer

(9) colon cancer

(10) hepatoma

(11) esophageal carcinoma

(12) gastric cancer

(13) malignant melanoma

(14) myeloproliferative disorder


Connective tissue disorders associated with nonbacterial endocarditis:

(1) systemic lupus erythematosus (SLE)

(2) antiphospholipid syndrome

(3) giant cell arteritis


Other chronic diseases associated with nonbacterial endocarditis:

(1) diabetes

(2) cirrhosis


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