Interstitial Granulomatous Dermatitis with Arthritis (IGDA) may be associated with a number of clinical conditions. It may appear before the underlying condition is recognized.
Synonym: Ackerman's syndrome
Autoimmune disease:
(1) rheumatoid arthritis
(2) systemic lupus erythematosus (SLE)
(3) primary biliary cirrhosis
(4) autoimmune thyroiditis
(5) autoimmune hepatitis
Infectious disease:
(1) chronic hepatitis C with cryoglobulinemia
(2) coccidioidomycosis
(3) borreliosis
Drug-induced:
(1) PD-1 inhibitor therapy
(2) gabapentin
(3) trastuzumab (Herceptin)
(4) TNF-blocker
(5) anticonvulsants
(6) antihypertensive agents
Paraneoplastic syndrome:
(1) myelodysplasia
(2) solid malignancy (prostate, esophagus, other)
(3) malignant lymphoma
(4) multiple myeloma
Differential diagnosis:
(1) necrobiosis lipoidica diabeticorum
(2) granuloma annular
(3) histiocytoid Sweet syndrome
