Patients with abnormalities in glucose-6-phosphate dehydrogenase can be separated into different classes based on clinical and laboratory findings.
(1) chronic hereditary, nonspherocytic hemolytic anemia
(2) severe enzyme deficiency
(3) mild enzyme deficiency
(4) gene mutation with normal functional activity
While the chronic hemolytic anemia is usually mild, some patients may have severe anemia with transfusion dependence.
Patients with low levels of functional activity may present following hemolysis occurring after exposure to a precipitating drug or compound.
Functional Level of Enzyme Activity
<= 25% of normal
26 – 64% of normal
from page 16, WHO 1967
• The percent activities were adjusted to remove overlap in ranges at 25% and 65%
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Specialty: Hematology Oncology, Clinical Laboratory