A dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arising from an existing well-differentiated liposarcoma.
The typical patient is an elderly adult.
Features of a de-differentiated liposarcoma:
(1) The patient has a history of, or evidence for, a well-differentiated liposarcoma.
(2) In the same area the patient has a high-grade sarcoma without fat (nonlipogenic) such as pleomorphic, MFH, myxoid, etc.
(3) The gross appearance shows areas of lipoma-like adipose tissue adjacent to or intermixed with discrete, solid, often fleshy tissue.
(4) Molecular testing tends to show findings similar to a well-differentiated liposarcoma (MDM2 and/or CPM associated with 12q13-15).
(5) It occurs most often in the retroperitoneum, but it can occur in any body site.
(6) If it metastasizes then it often goes to the lungs.
To read more or access our algorithms and calculators, please log in or register.
Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic
