The clinical and laboratory findings of a mast cell disorder are influenced by the nature of the mast cell proliferation, its total volume, its distribution and the release of cytoplasmic products such as histamine..


Constitutional findings:

(1) fatigue

(2) weight loss

(3) fever

(4) sweating

(5) flushing


Cutaneous lesions:

(1) skin lesions (macules, papules, nodules, blisters, bullae)

(1a) skin lesions may be pigmented

(1b) Darier's sign (skin lesions urticate after being stroked)

(2) pruritis

(3) dermatographism


Gastrointestinal symptoms:

(1) nausea and vomiting

(2) abdominal pain

(3) diarrhea

(4) peptic ulcer

(5) hepatomegaly

(6) splenomegaly


Musculoskeletal symptoms:

(1) bone pain

(2) muscle pain

(3) pathologic fracture

(4) arthralgias


Cardiopulmonary symptoms:

(1) tachycardia

(2) abnormal blood pressure (hypotension or hypertension)

(3) dyspnea

(4) wheezing


Neurologic symptoms:

(1) syncope

(2) headache


Hematologic findings:

(1) variable anemia

(2) variable abnormality in the WBC count (leucopenia, leukocytosis)

(3) variable abnormality in the platelet count (thrombocytopenia, thrombocytosis)

(4) eosinophilia

(5) lymphadenopathy


To read more or access our algorithms and calculators, please log in or register.