Clinical findings:
(1) splenomegaly, which may be marked
(2) skin rash
(3) hepatomegaly
(4) frequent infections
(5) B symptoms (fever, night sweats, weight loss)
Autoimmune paraneoplastic findings:
(1) inflammatory arthropathy, often rheumatoid arthritis (RA)
(2) autoimmune thyroiditis
(3) pure red cell aplasia
(4) immune thrombocytopenic purpura (ITP)
(5) SLE
A patient may develop Felty’s syndrome (RA with marked splenomegaly).
Laboratory findings:
(1) neutropenia
(2) anemia
(3) thrombocytopenia
(4) antinuclear antibodies (ANA)
(5) rheumatoid factor (RF)
(6) beta-2 microglobulinemia
(7) hypergammaglobulinemia
(8) atypical lymphocytosis
