Drug-induced agranulocytosis is associated with a number of clinical and laboratory findings.
(1) high fevers
(4) necrotic ulcerations involving the pharynx and the tonsils
(6) skin eruption
(7) infrequently septic shock
(1) low absolute neutrophil count < 500 per µL (absolute neutropenia)
(2) other leukocytes present
(3) no or mild anemia (hematocrit >= 30%)
(4) no or mild thrombocytopenia (platelet count >= 100,000 per µL) unless DIC occurs
(5) absence of anti-neutrophil antibodies
Discontinuation of the causative drug should result in recovery of the neutrophil count in 2 to 4 weeks.
(1) aplastic or hypoplastic anemia
(2) megaloblastic anemia
(3) leukemia or lymphoma
(4) autoimmune disease
(6) infectious or post-infectious neutropenia
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Specialty: Hematology Oncology, Clinical Laboratory