Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare hematologic disorder that can be a challenge to diagnose. Some patients benefit from aggressive therapy, and early diagnosis benefit these patients..


The condition usually occurs in older adults but can occur at any age.


Clinical features:

(1) skin lesions (nodules, plaques, bruise-like lesions), which may be solitary or multifocal

(2) variable fever

(3) variable lymphadenopathy

(4) variable hepatomegaly and/or splenomegaly


Laboratory features:

(1) thrombocytopenia

(2) variable leukemia (circulating tumor cells)


Differential diagnosis of cutaneous involvement:

(1) SLE

(2) cutaneous lymphoma

(3) leukemia cutis


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