Wegener's Granulomatosis (WG) can be diagnosed using a classification tree approach.
top level |
second level |
third level |
fourth level |
diagnosis |
granulomatous inflammation present on biopsy (or hemoptysis if no biopsy data) |
nasal or oral inflammation present |
|
|
WG |
|
nasal or oral inflammation absent |
abnormal chest radiograph |
|
WG |
|
|
normal chest radiograph |
|
non-WG |
granulomatous inflammation absent on biopsy (or no hemoptysis if no biopsy data) |
nasal or oral inflammation present |
abnormal chest radiograph |
|
WG |
|
|
normal chest radiograph |
abnormal urine sediment |
WG |
|
|
|
normal urine sediment |
non-WG |
|
nasal or oral inflammation absent |
|
|
non-WG |
where:
• The criteria are the same as for the traditional format.
• Hemoptysis present during the illness can be used if biopsy data is not available
Patient Subsets |
Findings |
WG patients |
absence of granulomatous inflammation on biopsy; nasal or oral inflammation present; abnormal chest radiograph |
|
absence of granulomatous inflammation on biopsy; nasal or oral inflammation present; normal chest radiograph; abnormal urine sediment |
|
granulomatous inflammation on biopsy; nasal or oral inflammation present |
|
granulomatous inflammation on biopsy; absence of nasal or oral inflammation; abnormal chest radiograph |
non-WG patients |
absence of granulomatous inflammation; absence of nasal or oral inflammation |
|
absence of granulomatous inflammation; nasal or oral inflammation present; normal chest radiograph; normal urinary sediment |
|
granulomatous inflammation on biopsy; absence of nasal or oral inflammation; normal chest radiograph |
Performance:
• The sensitivity is 87.1% and specificity is 93.6%
Specialty: Immunology/Rheumatology
ICD-10: ,