Wu et al proposed a classification for primary effusion-based lymphomas (PEL). This is a modification of a classification proposed by Carbone and Gloghini. The authors are from the University of California at Irvine.
Parameters:
(1) HHV-8 status
(2) immunophenotype
(3) morphology
(4) additional testing
HHV-8 |
Phenotype |
Morphology |
Additional Testing |
Diagnosis |
positive |
NA |
NA |
NA |
HHV-8(+) PEL |
negative |
T cell |
NA |
NA |
T cell PEL-like ENL |
negative |
plasma cell |
NA |
NA |
HHV-8(-) PEL |
negative |
indeterminate |
NA |
NA |
HHV-8(-) PEL |
negative |
B cell |
Burkitt-like |
c-myc rearrangement, high Ki-67 (near 100%) |
Burkitt PEL-like ENL |
negative |
B cell |
large cell |
features of Burkitt's absent |
large B cell PEL-like ENL |
where:
• ENL = extra-nodal lymphoma
Specialty: Hematology Oncology