Description

Talbot et al classified the severity of acute intoxication with the herbicide Roundup. This can help identify patients who may require closer monitoring and more aggressive management. The authors are from Changhua Christian Hospital in Changhua, Taiwan.


 

Toxin involved: glyphosate (N-phosphonomethyl glycine)

 

If the person has no complaints, no abnormalities on physical examination and no abnormalities in laboratory testing, then he or she is considered asymptomatic.

 

Mild intoxication - resolved within 24 hours and vital signs stable:

(1) nausea and vomiting

(2) diarrhea

(3) abdominal pain

(4) mouth and throat pain

 

Moderate intoxication:

(1) GI symptoms (above) lasting more than 24 hours

(2) GI hemorrhage

(3) esophagitis or gastritis on endoscopy

(4) oral ulceration

(5) hypotension responsive to fluid resuscitation

(6) pulmonary dysfunction not requiring intubation

(7) acid-base disorder

(8) transient hepatic damage

(9) transient renal damage or temporary oliguria

 

Severe intoxication:

(1) pulmonary dysfunction requiring intubation

(2) renal failure requiring dialysis

(3) hypotension requiring pressor therapy

(4) cardiac arrest

(5) hepatic failure

(6) coma

(7) seizures

(8) death

 

where:

• Hepatic failure was not listed in the table, but was included due to the reference to transient hepatic dysfunction under moderate intoxication.

• I did not include death in the spreadsheet since that seemed pretty self-evident.

 


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