One of the most common and serious complications of anticoagulation is bleeding. Assessing the severity of the bleeding is important in guiding patient management.


Criteria for major bleeding - one or more of the following:

(1) decrease in hemoglobin concentration >= 2 g/dL

(2) need to transfuse >= 2 units of red cell units

(3) intracranial bleeding

(4) retroperitoneal bleeding


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