Sarcopenia may classified based on by cause. In many patients the sarcopenia is multifactorial. Identifying the cause is the first step in formulating an appropriate management strategy.
advanced age as the only explanation
activity-related (extrinsic cause)
prolonged bed rest, inactivity (sedentary lifestyle), disuse with deconditioning, zero-gravity
protein and/or calorie malnutrition, anorexia, starvation
secondary to organ failure, cancer, endocrine or metabolic disorder, chronic inflammatory disease, neurodegenerative
drug or toxin-induced
more than one of the above categories
• Age-related sarcopenia is termed primary if no other cause is found. However, the term primary may be better reserved if no underlying cause is found.
Sarcopenia due to disease can be divided into:
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