Kumar et al classified the severity of veno-occlusive disease (VOD) based on clinical findings. The authors are from the Mayo Clinic and the University of Southern California.
Liver Disease
Treatment for VOD
Severity
no adverse effects; any illness is self- limited
none required
mild
adverse effects occur but resolve by day 100
responds to medical therapy
moderate
adverse effects occur with signs and symptoms persisting beyond day 100; patient dies of complications directly attributable to VOD
does not respond to therapy
severe
where:
• Medical therapy includes diuretics for fluid retention and analgesics for pain associated with hepatomegaly.
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