Hemorrhagic Disease of the Newborn (HDNB) can be classified based on the time of clinical onset.
Time of Onset |
Term |
Typical Cause |
<= 24 hours old |
early onset |
maternal drug that affects vitamin K function or maternal vitamin K deficiency |
2 to 7 days old |
classic |
failure to give a prophylactic dose of vitamin K after delivery, delayed feeding |
3 to 8 weeks old |
late onset |
inadequate vitamin K intake or malabsorption |
Neonates usually have low vitamin K levels at birth because delivery of vitamin K across the placental barrier is poor.
Maternal drugs that may affect vitamin K function:
(1) antituberculous (isoniazid)
(2) anticonvulsant (paper of Kazmin et al indicates that this is unlikely)
Specialty: Hematology Oncology, Clinical Laboratory, Nutrition, Pharmacology, clinical, Pedatrics