Hemorrhagic Disease of the Newborn (HDNB) can be classified based on the time of clinical onset.
Time of Onset
Term
Typical Cause
<= 24 hours old
early onset
maternal drug that affects vitamin K function or maternal vitamin K deficiency
2 to 7 days old
classic
failure to give a prophylactic dose of vitamin K after delivery, delayed feeding
3 to 8 weeks old
late onset
inadequate vitamin K intake or malabsorption
Neonates usually have low vitamin K levels at birth because delivery of vitamin K across the placental barrier is poor.
Maternal drugs that may affect vitamin K function:
(1) antituberculous (isoniazid)
(2) anticonvulsant (paper of Kazmin et al indicates that this is unlikely)
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Specialty: Hematology Oncology, Clinical Laboratory, Nutrition, Clinical Pharmacology, Pedatrics
