Fukunaga et al evaluated the response in patients with cholinergic urticaria to skin tests using autologous fluids. This can help to classify a patient into one of 2 major groups. The authors are from Kobe University.
Patients with cholinergic urticaria will show an increase in plasma histamine after an exercise challenge.
Autologous fluids used for skin testing:
(1) diluted sweat
(2) serum
Response to Sweat
Response to Serum
Subtype
strong
negative
nonfollicular
weak
positive
follicular
where:
• The eruption in the follicular subtype involves the hair follicles.
• The increase in plasma histamine is greater with the nonfollicular subtype.
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