Leroy et al classified an infection with a Candida species as isolated Candidemia or invasive based on clinical and microbiological findings. The authors are from multiple hospitals in France participating in the AmarCand Study Group.
Parameters:
(1) blood culture
(2) culture from a normally sterile site
(3) signs of infection at site(s)
Term
Blood Culture
Culture of Normally Sterile Site
Signs of Infection at Site
isolated candidemia
>= 1 positive
negative
NA
invasive candidiasis with candidemia
>= 1 positive
>= 1 positive
present
invasive candidiasis without documented candidemia
0 positive (all negative)
>= 1 positive
present
where:
• Normally sterile sites include peritoneal fluid, lung parenchyma, etc.
• A central venous catheter (CVC) was not considered a sterile site.
• An isolate from the blood and normally sterile site should be the same.
Additional terms that can be used:
Term
Features
colonization
persistently positive cultures of a site not blood AND not normally sterile
dissemination
positive cultures from multiple, noncontiguous normally sterile sites
contamination
positive culture of blood or nonsterile site caused by inclusion of material from a nonsterile, colonized site
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