Primary natural killer cell deficiencies (NKD) may be classified based on their characteristics.
Types
NK Cells
Infection Susceptibility
classic (CNKD)
absent or very low
herpesvirus
functional (FNKD)
present but little or no function
herpesvirus, papillomavirus
Subtype CNKD
Gene
Inheritance
Susceptible to
CNKD1
GATA2
auto dominant
VZV, HSV, CMV, HPV, M. tuberculosis, Trichophyton
CNKD2
MCM4
auto recessive
EBV, HSV
other
??
Subtype FNKD
FNKD1
FCGR3A
HSV, EBV, HPV
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Specialty: Immunology/Rheumatology
