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Staph Aureus | CART Analysis for Predicting Response to Vancomycin

Purpose: To evaluate a patient with a nosocomial pneumonia due to Staphylococcus aureus and treated with vancomycin based on the CART analysis of Moise et al.

Description

Moise et al used a classification and regression tree (CART) analysis to evaluate the response of a nosocomial pneumonia due to Staphylococcus aureus to vancomycin therapy. The authors are from Millard Fillmore Hospital and State University of New York (SUNY) at Buffalo.


The culture isolates consists of both methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus.

 

Parameters:

(1) ratio of the area under the antibiotic curve to MIC

(2) number of days between admission and onset of the lower respiratory tract infection (length of stay prior to occurrence of the lower respiratory tract infection)

(3) estimated creatinine clearance in mL per min

 

The area under the 24 hour antibiotic curve is reported in mg • h/L

 

The MIC is reported in µg/mL, which is equivalent to mg/L

 

Ratio of AUC to MIC

Length of Stay to Onset

Creatinine Clearance

Success (Eradication)

> 866

NA

NA

91%

<= 866

>= 12 days

NA

25%

<= 866

< 12 days

> 34

80%

<= 866

< 12 days

<= 34

13%

 


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Specialty

Objective

ICD-10