Features of CMC:
(1) The patient suffers recurrent or persistent infections with Candida albicans and sometimes other Candida species.
(2) The infections may involve the skin, oral mucosa, esophagus, genital mucosa and nails.
(3) There is a variable predisposition to infection with Staphylococcus aureus.
(4) Disseminated or systemic candidiasis is uncommon.
Skin lesions may take the form of:
(1) papular rash
(2) erythematous scaling plaques
(3) Candida granulomas (boggy hyperkeratotic lesions)
People who develop CMC have one of the following:
(1) hereditary defects in host immunity, affecting IL-17 immunity, CARD9 or STAT3 (hyper-IgE syndrome)
(2) anti-cytokine antibodies
(3) acquired immunosuppression (HIV, corticosteroids, diabetes, etc)
