Infectious mononucleosis may be associated with fatigue. Petersen et al identified certain factors that can help to identify a patient at increased risk for fatigue. The authors are from Barts and The London Queen Mary's School of Medicine and Dentistry and the University of Bristol.

Infections associated with fatigue may include:

(1) infectious mononucleosis

(2) aseptic meningitis

(3) viral hepatitis


Fatigue seen with infectious mononucleosis may be:

(1) acute (during the first 8 weeks after onset)

(2) subacute

(3) chronic (beyond 6 months)


Risk factors for fatigue:

(1) female gender

(2) pre-existing mood (depressive) disorder


When looking at persistent fatigue it is necessary to distinguish:

(1) persistent or recurrent infectious mononucleosis (rare)

(2) depression

(3) chronic fatigue not explained by these 2 diagnoses

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