Cholestyramine is an anion exchange resin with several uses, one of which is in the therapy of hyperthyroidism.

Mechanism of action: reduce the enterohepatic circulation of thyroid hormones. Thyroid hormone is conjugated with glucuronides and sulfates in the liver and excreted in the bile. Some conjugated forms deconjugate in the intestines and are reabsorbed.


It is used as adjunctive therapy for other drugs that reduce thyroid hormone production.



(1) Graves' disease

(2) thyroiditis

(3) iodine-induced hyperthyroidism


Cholestyramine can interfere with absorption of several drugs. It is important to make sure that it does not interfere with the other antithyroid medications.

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