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Chemotherapy-Induced Splenic Enlargement and Perioperative Complications in Patients Undergoing Hepatic Resection of Metastatic Colorectal Cancer

Description

Simpson et al monitored the change in splenic volume associated with chemotherapy in patients undergoing hepatic resection for metastatic colorectal cancer. Patients with a significant increase in splenic volume were at greater risk for complications following surgery. The authors are from Memorial Sloan Kettering Cancer Center and Vanderbilt University.


 

Patient selection: metastatic colorectal cancer with chemotherapy for 6 months prior to resection of metastases

 

Imaging studies: CT or MRI with splenic volumetry

 

Parameters:

(1) splenic volume at baseline in mL

(2) splenic volume 6 months later

 

change in splenic size =

= ((splenic volume at 6 months) - (splenic volume at baseline)) / (splenic volume at baseline) * 100%

 

Interpretation:

• An increase in splenic volume >= 39% was associated with major complications following surgery.

 


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