Paniccia et al identified characteristics associated with long-term survival with pancreatic ductal adenocarcinoma. The authors are from the University of Colorado.
Patient selection: pancreatic ductal adenocarcinoma
Parameters:
(1) lymph node ratio (positive to number examined)
(2) chemotherapy
(3) T status
(4) age in years
(5) surgical margin
(6) tumor differentiation (grade)
(7) M status
(8) tumor diameter in cm
(9) percent of population living in zip code with a high school diploma
(10) insurance status
|
Parameter |
Finding |
Points |
|
lymph node ratio |
> 20% |
0 |
|
|
1 to 20% |
4 |
|
|
0% |
5 |
|
|
unknown |
3 |
|
chemotherapy |
none |
0 |
|
|
neoadjuvant |
0 |
|
|
adjuvant |
3 |
|
T status |
T4 |
0 |
|
|
T3 |
2 |
|
|
T2 |
3 |
|
|
T1 |
4 |
|
|
T0 or X |
3 |
|
age in years |
> 80 |
0 |
|
|
70 to 80 |
2 |
|
|
60 to 70 |
2 |
|
|
50 to 60 |
4 |
|
|
< 50 |
4 |
|
surgical margin |
positive |
0 |
|
|
negative |
2 |
|
|
unknown |
2 |
|
tumor differentiation |
poorly differentiated |
0 |
|
|
moderately differentiated |
2 |
|
|
well differentiated |
3 |
|
|
other (? unknown) |
1 |
|
M status |
M1 |
0 |
|
|
M0 or MX |
6 |
|
tumor size |
< 2 cm |
2 |
|
|
2 to 4 cm |
0 |
|
|
> 4 cm |
0 |
|
|
unknown |
0 |
|
educational level |
<= 71% |
0 |
|
|
71.1 to 80% |
1 |
|
|
80.1 to 86% |
1 |
|
|
> 86% |
2 |
|
|
not available |
0 |
|
insurance status |
not insured |
0 |
|
|
private |
2 |
|
|
Medicaid or Medicare |
2 |
|
|
unknown |
4 |
where:
• The M status in Table 3 is given as M1 or MX.
• The educational level ranges has a gap at 80.1 to 81.0%.
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0 (minimum in studies appears to have been 4)
• maximum score: 35
• The higher the score the greater the chance of having a 10-year surivival.
|
Total Score |
10-Year Survival Rate |
|
<= 9 |
0% |
|
0.4% |
|
|
13-15 |
0.6% |
|
16-18 |
0.8% |
|
19-21 |
1.8% |
|
22-24 |
4.5% |
|
25-27 |
9.5% |
|
>= 28 |
18% |
Performance:
• The area under the ROC curve is 0.77.
Specialty: Hematology Oncology
