Oikonomou et al reported the Childhood & Adolescence Cancer Survivor Cardiovascular (CHACS-CV) Risk Score for predicting the risk of cardiovascular disease in a childhood cancer survivor. This can help to identify a patient who may require closer monitoring. The authors are from multiple institutions in Greece, England and the United States.
Patient selection: survivor of childhood cancer (date of diagnosis <= 19 years of age)
Parameters:
(1) age at cancer diagnosis
(2) sex
(3) history of lymphoma
(4) history of any radiation
(5) race
Parameter
Finding
Points
age at diagnosis
< 10 years
0
10 to 14 years
1
15 to 19 years
2
sex
female
0
male
1
history of lymphoma
no
0
yes
2
history of any radiation
no
0
yes
2
race
White
0
other
1
total CHACS-CV score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 8
• The risk increases as the score increases.
Score
Risk
25-Year CV Mortality
0 to 3
low
0.7%
4 or 5
intermediate
2.6%
6 to 8
high
6%
Performance:
• The area under the ROC curve is 0.73.
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