Greenberg et al reported criteria for the diagnosis of cerebral amyloid angiopathy (CAA). The authors are from Massachusetts General Hospital.
Types of criteria:
(1) with pathology data
(2) without pathology data (clinical, MRI, CT)
Criteria for definite CAA:
(1) full postmortem exam
(2) lobar, cortical or cortical-subcortical hemorrhage
(3) severe CAA with vasculopathy
(4) absence of other diagnostic lesion (head trauma, hemorrhagic transformation of ischemic stroke, arteriovenous malformation, hemorrhagic tumor, INR > 3, vasculitis)
Pathologic criteria for probable CAA
(1) some degree of CAA in pathologic specimen
(2) lobar, cortical or cortical-subcortical hemorrhage (includes cortical superficial siderosis, intracerebral or cerebral microbleed)
(3) absence of other diagnostic lesion
Nonpathologic criteria for probable CAA:
(1) age >= 55 years
(2) one of the following:
(2a) multiple hemorrhages restricted to lobar, cortical or cortical-subcortical regions, with or without cerebellar hemorrhage
(2b) single lobar, cortical or cortical-subcortical hemorrhage AND cortical superficial siderosis
(3) absence of other causes of hemorrhage
Nonpathologic criteria for possible CAA:
(1) age >= 55 years
(2) one of the following:
(2a) single hemorrhage restricted to lobar, cortical or cortical-subcortical regions
(2b) cortical superficial siderosis
(3) absence of other causes of hemorrhage
