The Centers for Disease Control and Prevention (CDC) has listed criteria for possible sepsis in an adult based on records in the electronic medical record, referred to as the eSOFA.

Criteria for an adult sepsis event (ASE) - both of the following:

(1) presumed infection - both of the following:

(1a) blood culture obtained (irrespective of result)

(1b) at least 4 qualifying antimicrobial days, starting in a period from 2 days before to 2 days after blood culture collected

(2) dysfunction in >= 1 organ systems in a period from 2 days before to 2 days after blood culture collected


Organ systems:

(1) cardiovascular

(2) pulmonary

(3) renal

(4) hepatic

(5) coagulation

(6) perfusion dysfunction


Organ System



initiation of a new vasopressor (norepinephrine, epinephrine, dopamine, phenylephrine, vasopressin)


initiation of mechanical ventilation (> 1 calendar day required between ventilator episodes)


(1) doubling of the serum creatinine or (2) >= 50% decline in eGFR (excluding patients with end-stage renal disease)


serum total bilirubin >= 2.0 mg/dL AND increase by >= 100% from baseline (doubling)


platelet count less than 100,000 per microliter AND >= 50% decline from baseline (with baseline >= 100,000 per µL)

perfusion dysfunction

serum lactate >= 2.0 mmol/L



• SOFA includes a neurologic evaluation, not used with eSOFA.

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