Criteria 1: organism isolated from culture of pericardial tissue or fluid obtained by needle aspirate or during surgery
Criteria 2 - all of the following:
(1) patient age > 12 months
(2) 2 or more of the following symptoms
(2a) fever (> 38° C)
(2b) chest pain
(2c) paradoxical pulse
(2d) increased heart size
(3) no other recognized cause for the symptoms
(4) one or more of the following:
(4a) abnormal ECG consistent with myocarditis or pericarditis
(4b) positive antigen test on blood
(4c) histologic examination of heart tissue shows evidence of myocarditis or pericarditis
(4d) fourfold rise in type-specific antibody with or without isolation of virus from pharynx or feces
(4e) pericardial effusion identified on echocardiogram, CT scan, MRI, angiography or other radiographic evidence of infection
Criteria 3 - all of the following:
(1) patient age <= 12 months
(2) 2 or more of the following symptoms:
(2a) fever (> 38° C) or hypothermia (< 37°C)
(2b) apnea
(2c) bradycardia
(2d) paradoxical pulse
(2e) increased heart size
(3) no other recognized cause for the symptoms
(4) one or more of the following:
(4a) abnormal ECG consistent with myocarditis or pericarditis
(4b) positive antigen test on blood
(4c) histologic examination of heart tissue shows evidence of myocarditis or pericarditis
(4d) fourfold rise in type-specific antibody with or without isolation of virus from pharynx or feces
(4e) pericardial effusion identified on echocardiogram, CT scan, MRI, angiography or other radiographic evidence of infection
