Minimal Change Disease (MCD) may be associated with a number of conditions. Controlling the cause is important for managing the patient.
Secondary causes of MCD:
(1) NSAID
(2) lithium
(3) bee stings (? allergy)
(4) food allergy
(5) EBV infection
(6) HIV infection
(7) paraneoplastic (see next)
Tumors associated with paraneoplastic MCD (all hematologic):
(1) Hodgkin’s lymphoma
(2) non-Hodgkin’s lymphoma
(3) intravascular (angiotrophic) lymphoma
(4) angioimmunoblastic lymphadenopathy
(5) T cell leukemia
(6) mycosis fungoides
(7) acute myelogenous leukemia
(8) chronic myelogenous leukemia
Idiopathic/primary MCD
Variant forms of MCD:
(1) diffuse mesangial hypercellularity
(2) IgM nephropathy
(3) with acute renal failure
(4) in combination with IgA nephropathy
(5) in combination with lupus nephritis
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Specialty: Nephrology, Clinical Laboratory
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