The bone isoenzyme of alkaline phosphatase may be elevated in a number of conditions, especially those associated with osteoblastic activity..
Situations where the bone isoenzyme of alkaline phosphatase may be elevated:
(1) pediatric population, associated with bone growth
(2) Paget’s disease of bone
(3) metabolic bone disease
(4) osteosarcoma or other primary bone tumors
(5) metastatic carcinoma to bone
If a patient has cancer, then it is important to distinguish the bone isoenzyme from cancer-related isoenzymes. A patient with cancer metastatic to bone also may show increased liver isoenzyme if there are hepatic metastases.
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