Urine may appear dark brown or black if certain compounds are present. Sometimes the darkening occurs only after the urine has stood for several hours under conditions favoring oxidation (sunlight, air).
Darken on Standing (Oxidation) |
Comments |
melanogenuria (melanuria) |
metastatic melanoma or Addison's disease, hemochromatosis (see previous section) |
methemoglobin |
converted from hemoglobin, especially if urine acid |
gentisic acid |
metabolite of salicylates |
homogentisic acid |
in alkaptonuria, especially if urine alkaline |
indican (indol-3-yl sulfate, 3-indoxysulfuric acid) |
metabolite of tryptophan, seen in stagnant small bowel contents |
phenol poisoning |
|
bilirubin-biliverdin |
yellow foam, jaundiced |
Drugs causing brown or black urine:
(1) furazolidone
(2) iron sorbitol
(3) levodopa
(4) methyldopa (especially if oxidizing agents present)
(5) metronidazole
(6) nitrofurantoin
(7) phenacetin
(8) methocarbamol
Other causes:
(1) povidone iodine
(2) rhubarb
(5) tyrosinosis
(6) senna (leaves of Cassia senna used as a cathartic)
(7) nitrites
Specialty: Nephrology, Clinical Laboratory
ICD-10: ,