Hemoglobin A2 is comprised of 2 alpha and 2 delta globin chains. Hemoglobin A2 usually represents 1.5 to 3% of total hemoglobin.
Conditions associated with reduced hemoglobin A2:
(1) iron deficiency anemia
(2) hemoglobinopathies:
(2a) heterozygous hemoglobin Lepore
(2b) heterozygous hereditary persistence of hemoglobin F (HPHF), deletional type
(2c) a variant hemoglobin A2
(3) thalassemias
(3a) alpha-thalassemia
(3b) delta-beta thalassemia
(3c) delta thalassemia
(4) hematologic disorders:
(4a) sideroblastic anemia
(4b) juvenile chronic granulocytic leukemia
(4c) acute myeloid leukemia
The expected decrease in hemoglobin A2 may be masked if there is a concurrent condition that increases hemoglobin A2 (sse previous section).
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Specialty: Hematology Oncology, Clinical Laboratory
