Ichthyosis may be hereditary or acquired. Acquired ichthyosis can be causes by a range of conditions.

Ichthyosis is a thickened, dry, scaling of the skin that is typically symmetrical.


Conditions associated with acquired ichthyosis:

(1) paraneoplastic ichthyosis

(2) endocrine disorders (diabetes mellitus; hypothyroidism; autoimmune thyroiditis)

(3) drugs (clofazimine; statins; allopurinol; acitretin; EGFR inhibitors; BRAF inhibitors)

(4) nutritional deficiencies

(5) chronic renal disease

(6) chronic liver disease

(7) immune disorders (SLE; Crohn's disease; celiac disease; sarcoidosis)

(8) infections (tuberculosis; AIDS)


Some patients may have overlapping causes.


Correction of the underlying will often result in regression of the ichthyosis.

To read more or access our algorithms and calculators, please log in or register.