A cardiomyopathy with a restrictive phenotype can be seen in a range of genetic and acquired conditions. Identifying the cause can be important for management and prevention.
Familial/Genetic
(1) sarcomeric protein mutation
(2) essential light chain of myosin
(3) familial amyloidosis
(4) desminopathy
(5) pseudoxanthoma elasticum
(6) hemochromatosis
(7) Anderson-Fabry disease
(8) glycogen storage disease
(9) familial, NOS
(10) troponin I
(11) apolipoprotein
(12) Danon disease
The underlying genetic cause of a familial cardiomyopathy may be known or unknown.
Non-Familial causes:
(1) amyloid, non-familial
(2) scleroderma
(3) endomyocardial fibrosis
(4) hypereosinophilic syndrome
(5) carcinoid heart disease
(6) metastatic cancer
(7) radiation
(8) drugs (anthracycline, methysergide, ergotamine, mercurial agent, busulfan, serotonin)
(9) idiopathic
