A low serum inorganic phosphorus can be due to a number of conditions.

Conditions associated with hypophosphatemia include:

acidosis, including diabetic ketoacidosis

acute alcoholism

acute gout

acute liver failure


diuretic phase of severe burns

familial hypophosphatemic rickets

Gram-negative sepsis

growth hormone deficiency

hyperalimentation with insufficient phosphate

hypercalcemia, including familial hypocalciuric hypercalcemia

hyperparathyroidism (primary, secondary or paraneoplastic)



malabsorption or steatorrhea

osteoblastic metastases

primary hypophosphatemia

refeeding syndrome (phosphorus depletion syndrome)

renal tubular acidosis or renal tubular defects

respiratory alkalosis

salicylate poisoning

severe diarrhea

starvation or malnutrition

steroid excesss (glucocorticoids, anabolic, Cushing syndrome)

vitamin D deficiency

vomiting or nasogastric suction

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