Categories of Furth et al for Estimating the Time to End-Stage Renal Disease (ESRD) for a Pediatric Patient with Chronic Kidney Disease (CKD)

Description

Furth et al correlated categories of pediatric patients with chronic kidney disease with the rate of progression to end-stage renal disease. These can help to identify a patient who may benefit from more aggressive management. The authors are from the Chronic Kidney Disease in Children and ESCAPE Study investigators.

Patient selection: pediatric patient with chronic kidney disease

Outcome: need for renal replacement therapy, eGFR < 15, > 50% reduction in GFR)

Parameters at baseline:

(1) estimated GFR in mL per min per 1.73 square meter (CKiD of Schwartz et al)

(2) proteinuria based on urine protein to creatinine ratio (UPCR) in mg per mg creatinne

(3) diagnosis (glomerular vs nonglomerular)

estimated GFR	UPCR	Group
>= 90	< 0.5	A
	0.5 to 2.0	not available
	> 2.0	not available
60 to 89.9	< 0.5	A
	0.5 to 2.0	B
	> 2.0	C
45 to 59.9	< 0.5	A
	0.5 to 2.0	B
	> 2.0	D
30 to 44.9	< 0.5	B
	0.5 to 2.0	C
	> 2.0	E
15 to 29.9	< 0.5	D
	0.5 to 2.0	E
	> 2.0	F

Group	Diagnosis	50th Percentile
A	nonglomerular	> 10 yeares
	glomerular	> 10 yars
B	nonglomerular	> 10 years
	glomerular	6.2 years
C	nonglomerular	7.4 years
	glomerular	4.2 years
D	nonglomerular	4.0 years
	glomerular	2.3 years
E	nonglomerular	2.7 years
	glomerular	1.6 years
F	nonglomerular	1.3 years
	glomerular	0.8 years

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Categories of Furth et al for Estimating the Time to End-Stage Renal Disease (ESRD) for a Pediatric Patient with Chronic Kidney Disease (CKD)

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