A patient with multicentric Castleman's disease may present with a number of clinical and laboratory findings.


Common clinical findings:

(1) systemic constitutional findings (weight loss, night sweats, fever, fatigue)

(2) anemia

(3) generalized lymphadenopathy

(4) splenomegaly and/or hepatomegaly


Variable clinical findings:

(1) cutaneous rash

(2) vasculitis

(3) neurologic changes (seizures, peripheral neuropathy, other)

(4) peripheral edema

(5) effusions

(6) TTP

(7) autoimmune hemolytic anemia


Laboratory findings:

(1) polyclonal hypergammaglobulinemia

(2) hypoalbuminemia

(3) elevated C-reactive protein (CRP)

(4) elevated IL-6 and other cytokines

(5) elevated erythrocyte sedimentation rate (ESR)

(6) herpesvirus-8 viral load (HHV-8, Kaposi-sarcoma associated herpesvirus, KSHV) in all HIV-positive patients and many HIV-negative patients



(1) non-Hodgkin's malignant lymphoma (often plasmablastic)

(2) amyloidosis


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